Roy Zent, Ambra Pozzi, "Cell - Extracellular Matrix
Interactions in Cancer"
2010 | ISBN - 10: 1441908137 | 314 pages | PDF | 9 MB
Cancer was thought to originate from alterations in
intercellular signaling that resulted in the transformation
of cells, their uncontrolled proliferation and metastasis.
There is now an increasing body of evidence
demonstrating that the surrounding matrix and cell -
matrix interactions are also major players in this process.
Cells adhere and receive signals from various extracellular
matrices via transmembrane receptors, the best known of
which are the heterodimeric glycoproteins, integrins.
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